Wes invites his best friend Chris over for a night in after being dumped by Henry. They attempt to blow off some steam by prank calling strangers, but soon realize that may have been the worst idea ever.

Wes and Chris see a couples therapist and decide to explore opening the relationship to spice up their sex life. Cue a revolving door of painfully awkward hookup scenarios.

Flight attendants, Chris and Wes, instigate twisted mile-high games with passengers, leading to the unimaginable - maneuvering an emergency landing after someone poisoned the pilot.